Chemical analysis of E-cigarette fluids using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS)

Abstract

The analysis of e-cigarette (EC) fluids by high performance liquid chromatography (HPLC) or gas chromatography (GC) coupled to mass spectrometry (MS), GC hyphenated to flame-ionisation detection (FID), or nuclear magnetic resonance (NMR) spectroscopy poses many challenges due to the complexity of the matrix and the overwhelming number of compounds present. In order to overcome these challenges, this study focused on the qualitative and quantitative detection of the various compounds classes produced by the pyrolysis of EC fluids using comprehensive two-dimensional gas chromatography – time-of-flight mass spectrometry (GC×GC-TOFMS). The increased peak resolution afforded by GC×GC-TOFMS permitted the detection of numerous toxic and volatile organic compounds (VOCs) that could not be detected or distinguished previously by the methods mentioned above.

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